\[ **keywords:** #Rabbits #Ovulation/Induced_ovulation #GnRH ] --- > [!cite] Citation > Dal Bosco, A., P.G. Rebollar, C. Boiti, M. Zerani, and C. Castellini. ‘Ovulation Induction in Rabbit Does: Current Knowledge and Perspectives’. *Animal Reproduction Science*, vol. 129, nos. 3–4 (2011). pp. 106–117. [https://doi.org/10.1016/j.anireprosci.2011.11.007](https://doi.org/10.1016/j.anireprosci.2011.11.007). > [!abstract] > The profitability of rabbit farms has increased in recent years due primarily to improvements in the management of reproduction and genetic selection. This review summarizes the most important scientific papers relating to ovulation in rabbit does dealing in particular with: (a) studies from 1905 to the present day relating to ovulatory mechanisms in rabbit does; (b) research on the primary gonadotrophin-releasing hormone (GnRH), its analogues and their functions; and (c) descriptions of parenteral and intravaginal (iv.) treatments for induction of ovulation in does and their reported efficacies. The addition of GnRH analogues via the seminal dose (iv.) fulfils the need for a welfareorientated method of inducing ovulation in rabbits. The structure, tissues, secretions, contractions, and innervations of the vagina in rabbits that can affect absorption profiles are reviewed in the context of recent reports of the achievement of high ovulation rates obtained by adding GnRH analogues directly to the seminal dose. This review demonstrates the possibility of ovulation induction in rabbits by the addition of GnRH synthetic analogues to the seminal doses and provides new perspectives for simplifying the AI technique. --- ‘For over a century, it has been well known that ovulation is induced by coitus in the rabbit (Heape, 1905).’ [[Dal Bosco et al., ‘Ovulation Induction in Rabbit Does’, 2011|(Dal Bosco et al. 2011, 107)]] ^fa62e0 ‘The rabbit is considered to be in permanent estrus in that it is a “reflex” or “induced” ovulating species as opposed to a mammal that undergoes spontaneous ovulation (Hammond and Marshall, 1925).’ [[Dal Bosco et al., ‘Ovulation Induction in Rabbit Does’, 2011|(Dal Bosco et al. 2011, 107)]] ^42818d ‘Mature follicles in the ovaries of rabbit does grow and regress continuously such that the follicles in the preovulatory phase are almost always present. If mating does not occur, the ovarian follicles have been reported to maintain large dimensions (about 1.2–1.5 mm in diameter) for 7–10 days (Büttner and Wienert, 1935) or 12–16 days (Shibata, 1931; Hill et al., 1934).’ ‘Concomitant with the LH peak, an ovarian release of PGs occurs and may play a role in inducing follicular stigma rupture. … Four to five hours post-coitus, LH levels return to baseline values, and a new FSH peak stimulates the growth of new follicles until the antral stage 16–22 h later.’